Beyond Repair
Hyaline Cartilage Regeneration
CartiFuse develops breakthrough cartilage regeneration technology to treat knee osteoarthritis and osteochondral defects, with true hyaline cartilage regeneration
350M+
Global OA Patients$19.2B
Market by 2032True
Hyaline Regeneration
The Growing Crisis of Osteoarthritis
Osteoarthritis affects millions worldwide, with current treatments offering limited long-term solutions and significant drawbacks
350M+
People worldwide suffer from osteoarthritis, making it one of the most prevalent joint diseases globally.
Rising Trends
Aging populations, obesity rates, and sedentary lifestyles are driving exponential growth in OA cases.
Limited Solutions
Current treatments like microfracture produce fibrocartilage, not true hyaline cartilage regeneration
Current Treatment Limitations
Microfracture Surgery
Creates fibrous or hyaline-like cartilage instead of hyaline cartilage, leading to inferior mechanical properties and durability
Conservative Management
Pain management and physical therapy provide temporary relief without addressing root causes
Technology Solutions
Not suitable for young patients with cartilage injuries, limited lifespan, and an artificial joint may predispose patients to significant complications
Our Revolutionary Solution
True Hyaline Cartilage Regeneration
CartiFuse’s breakthrough biphasic plug technology enables authentic hyaline cartilage regeneration, offering a superior alternative to current treatments
How Cartifuse Works
Bioactive polymer cap acts as scaffold for subchondral bone and hyaline cartilage regeneration
Bioactive polymer body gradually bioresorbs and osteointegrates with surrounding bone
Histopathological Assessment of Knee Joint Tissue
Tissue sample showing embedded plug and hyaline cartilage layer over plug
True Hyaline
Regenerates hyaline cartilage, not inferior fibrocartilage
Minimally Invasive
Muscle sparing apprach with faster recovery times
Durable Results
Continual cartilage regeneration backed by superior mechanical properties
True Hyaline
Precise treatment of focal cartilage defects with optimal integration
Advanced Technology Platform
Our proprietary biphasic plug technology represents a breakthrough in cartilage regeneration, combining advanced biomaterials with innovative design principles
Biphasic Design Innovation
Our unique two-layer architecture optimizes immediate protection and long-term regeneration, addressing key limitations of existing repair methods such as non-hyaline cartilage regeneration and donor site morbidity
Bioactive Polymer Cap
Supports hyaline cartilage regeneration and provides immediate mechanical protection during the regeneration process
Bioresorbable Body
Biodegradable scaffold that gradually resorbs while supporting tissue growth
Integrated Architecture
Seamless integration between layers ensure optimal load distribution with ideal porosity promoting desired cellular response
Cartifuse Device
Fast Integration
Gradual Resorption
Biphasic Architecture
Dual-layer design optimizes protection and regeneration phases
Biocompatible Materials
Materials selected with history of use in joint repair for safety and efficacy
Controlled Degradation
Precisely timed resorption matches natural regeneration timeline
Precision Manufacturing
Advanced fabrication ensures consistent quality and performance
Mechanism of Action Timeline
0-2
Weeks 0-2
Implantation & Initial Integration
Polymer cap provides immediate protection
2-8
Weeks 2-8
Cell Infiltration Begins
Stem cells migrate into bioactive polymer matrix structure to aid cartilage and bone regeneration
8-16
Weeks 8-16
Active Regeneration
Hyaline and subchondral bone regeneration / proliferation over bioactive polymer cap
16+
Weeks 16+
Maturation
Mature hyaline cartilage regenerated over surface polymer cap. Bony osteointegration with bioresorption of implant body
Meet Our World Class Team
Our multidisciplinary team combines decades of experience in orthopaedic surgery, biomaterials research, clinical development, and commercial strategy.
Leadership Team
A/Prof Lincoln Liow
Co-founder, CMO
Consultant Orthopaedic Surgeon, SGH • Deputy Vice Chair Research, MSK ACP (Medical Device Development)
Zhaotan Xiao
Co-founder, CEO
Former Board Director of RDWC Industries & REDEX Group • Commodities Trader at JPMorgan, Dresdner Kleinwort & ANZ Bank • Raised >$200m for healthcare & climate tech start-ups
Scientific Advisors
A/Prof Andrew Tan
Scientific Advisor
Senior Consultant Sports Orthopaedic surgeon, SGH • Past Head of Department
Peter Sculco
Scientific Advisor
Attending Orthopedic Surgeon, Hospital for Special Surgery • Associate Professor, Weill Cornell Medical College
Dr Zhou Yixin
Scientific Advisor
Professor & Chairman at Joint Surgery Dept • Beijing Jishuitan Hospital
Institutional Affiliations
Get in Touch
Ready to learn more about CartiFuse? We would love to hear from investors, clinical partners, and potential collaborators